Thursday, January 4, 2024
Review of Time-to-Event Outcomes Analyzed in 50 Systematic Reviews Indicates Lack of Rigorous Reporting
Saturday, September 23, 2023
Collaboration between medical professional societies and health organizations can increase the efficiency of development efforts, reduce waste, and help share resources, knowledge, and skills within and across disciplines. However, an international needs assessment of guideline developers found that certain aspects of collaboration were specifically challenging, including difficulties reconciling differences in guideline methodology and the time required for establishing collaboration agreements.
Since then, McMaster University and the Guidelines International Network (G-I-N) have worked on developing a toolkit for organizations looking to inspire, guide, and facilitate their own collaborations. The toolkit, launched at this year's G-I-N conference in Glasgow, Scotland, includes access to helpful resources such as a Memorandum of Understanding template for establishing partnerships and a glossary for making sure all parties are on the same page regarding important terms. A list of collaboration-related publications offers further knowledge and guidance for aspiring collaborators.
Check out the toolkit here and stay posted for update and additions!
Friday, August 11, 2023
At the most recent GRADE Guideline Development Workshop held in Austin, Texas, our team was joined by two impressive scholars making moves in the field of evidence synthesis and evidence-based medicine. These scholars, Drs. Syed Arsalan Naqvi and Juan Ruiz, were selected to have their workshop registration fee waived based on their application materials, including a description of a current or proposed project to reduce bias in healthcare. They also had the opportunity to present on these topics and field questions from the other workshop attendees.
Syed Arsalan Ahmed Naqvi, M.B.B.S., presented on a current project to apply machine learning to develop an algorithm to automatically assess certainty of evidence in living systematic reviews within a living interactive evidence (LivE) framework. Certainty of evidence assessment requires "repetitive evaluations whenever new studies or updated reports of previously included studies are incorporated into the existing body of evidence," Dr. Naqvi explained. "The manual efforts required to assess certainty of evidence necessitate considerable time and resources, which become even more cumbersome with periodic updates." Dr. Naqvi's project described the proposal for "an adjudication system which leverages an interactive web-based graphical user interface and rule-based algorithms" for assessing certainty in the context of living systematic reviews of randomized controlled trials.
Of his experience at the workshop, Dr. Naqvi said, "“The GRADE guideline workshop was an enriching experience. It was well organized, and precise, focusing on the most important aspects of clinical guideline development. I really enjoyed the small group sessions with the faculty and the participants."
Dr. Juan Ruiz presented his proposal to implement a rapid review and question-and-answer program for hospitalists applying evidence-based medicine in everyday practice. "Doctors have questions every day at the point of care that are not always [addressed], Dr. Ruiz explained. "Factors associated with unanswered medical questions" include "lack of time" and "lack of knowledge and skills to apply evidence-based medicine tools." By training onco-hospitalists in GRADE and creating an accessible database with clinical questions, answers, and recommendations based on evidence-based methodologies, Ruiz hopes to help bridge this gap in the evidence-to-practice pipeline.
"I had the opportunity to participate as a Scholar of the Evidence Foundation in the US GRADE Network workshop in Austin, TX in May 2023," said Dr. Ruiz. "This workshop was focused on non-RCTs, an area of great interest to me since I work analyzing large national databases and electronic medical records of cancer patients. I presented and received valuable feedback for a project to be implemented in a cancer hospital to develop recommendations for daily practice using the GRADE approach. It was a very constructive three-day experience where I was able to learn new skills and share knowledge."
Interested in becoming a scholar? Applications to attend our next fully virtual fall workshop, held October 25-27, 2023, for free close on August 31. See application details here.
Monday, May 1, 2023
We at the U.S. GRADE Network are excited to announce that, for the first time ever, we have partnered with INGUIDE, a credentialing system for guideline developers, to offer free access to their Level 1 online training to participants of our Guideline Development Workshop and Guideline Fundamentals for Panel Members and Organization Staff pre-workshop course.
The INGUIDE program, the result of a collaboration between the Guidelines International Network (G-I-N) and McMaster University, provides certification of individuals involved in guideline development on four successive levels, from a Guideline Panel Member to becoming a Guideline Development Credentialing Instructor themselves.
- the importance of trustworthy guidelines
- checklists for the development of guidelines
- the structure and roles of a guideline panel
- the process of grading evidence and formulating recommendations
Tuesday, April 11, 2023
The U.S. GRADE Network's 18th workshop is just five weeks away! With a focus on assessing certainty of evidence informed by non-randomized studies, this workshop will take place in Austin, Texas - the home of Austin City Limits, the famous Bat Bridge, and some next-level barbecue joints.
We asked some of the workshop facilitators about what they're looking forward to about the trip (besides the chance to talk about GRADE and evidence-based medicine for three days straight!) Here's what they said...
Limited space remains for the workshop. Learn more and register and www.gradeconf.org.
Tuesday, January 17, 2023
Thanks to you, 2022 was one of our best years yet.
We were relieved to see you in person, our first time since 2020, at our spring workshop in Chicago last June! Then, we reconvened online for a virtual workshop in November. Overall, we hosted over 100 participants from around the world, stretching from Canada and Spain to Colombia and Sweden.
We also launched our new two-day virtual Systematic Review workshop offering and welcomed another 48 learners, including a record 13 scholars from across the globe!
We published our takeaways from our early experiences moving our workshop online in response to the Covid-19 pandemic in BMJ Evidence-Based Medicine, which you can read about here.
Finally, we launched the USGN Webinar Series and will host regular free webinars on all things GRADE. For our inaugural session, we were joined by Drs. Gordon Guyatt and Reem Mustafa. You can watch the recording and subscribe to our new YouTube channel here.
We look forward to seeing you at our 18th Guideline Development Workshop, in person in sunny Austin, Texas, May 17-19, 2023! The workshop will have a special focus on assessing the certainty of evidence informed by non-randomized studies. Registration is now open.
Tuesday, January 10, 2023
During our 17th GRADE Guideline Development Workshop, held virtually, the U.S. GRADE Network had the honor of introducing the three latest recipients of the Evidence Foundation scholarship to the virtual stage. On the third and final morning of the workshop, each scholar presented on their current projects to reduce bias in healthcare and move the field of evidence-based medicine methodology forward.
Abrar Alshorman, MBBS, presented on her work to examine the tools used to assess risk of bias across various types of evidence. As choosing the wrong risk of bias tool at the start of an evidence synthesis effort might waste time and disrupt workflow, her project aims to guide systematic reviewers in choosing the best tool to use. The resulting list includes risk of bias tools for use in primary studies that were identified in a search of the evidence, including those with applications in randomized, non-randomized, diagnostic test accuracy, prognosis, and qualitative bodies of evidence.
"The workshop struck the perfect balance between informative and interactive," said Alshorman. "[A]ll sessions have been extremely informative and provided by very knowledgeable presenters. This opportunity offered me insight into the key concepts of the GRADE approach for guideline development. I look forward to incorporating the information I've learned into practice."
Next, Brett Norling, a third-year medical student, discussed his project examining the use of the GRADE framework in systematic reviews in urology. The project reviewed literature published in the top 5 urology journals since 2000, using Perl programming code to identify articles using GRADE. The team then applied a 37-item checklist developed de novo from the "Criteria for Applying or Using GRADE." The results demonstrated that while most (95.8%) of the included reviews correctly applied GRADE on an outcome-level basis, nearly one-third (31.4%) of the 70 reviews summary of findings, evidence profile, or other from of table to present their findings.
"I came to the GRADE Workshop having performed a systematic review and a few other research projects regarding systematic review methodology," said Norling. "I felt that my understanding of GRADE was in the developing stages, though it felt a bit abstract prior to the workshop. Key GRADE principles of evidence assessment came to life as I worked with a small group to assess a body of evidence and arrive at a recommendation. I now feel well equipped to confidently assess evidence and perform systematic reviews with a greater level of autonomy than prior to this workshop."
Finally, Ariadna Alaudell-Rispau, a PhD candidate in the Biomedical Research Methodology and Public Health Doctoral Program at the Autonomous University of Barcelona, presented her proposal for the development of Living Evidence Structures Summaries (LESS). Auladell-Rispau described her project to lead a multi-design, iterative study that allows for a systematic and rigorous development of a "Living Evidence updates reporting model" that "accounts for the periodic and/or constant updates of the evidence syntheses developed under the Living Evidence model, permits the development of valid, reliable, and updated health information to health decision makers, including guideline or [health technology assessment] developers..., [and is] friendly and accessible." The project will include a systematic review, brainstorming meetings, a Delphi consensus process, and finally, testing and assessment of the newly developed model.
We look forward to updating the blog about these projects as they move forward!
ANNOUNCEMENT: Applications for the Spring 2023 GRADE Guideline Development Workshop, held in Austin, Texas, May 17-19, 2023, are due February 28th! Learn more about the application requirements here and read about the workshop details here.